Research Associate In Vitro And Cellular Compound Profiling In Targeted Protein Degradation

SERAC Biosciences AG is looking for a Research Associate in vitro and cellular compound profiling in Targeted Protein Degradation.

Ridgeline Discovery, a Versant Ventures Discovery Engine, creates and operates Versant-financed innovative biotech companies in partnership with entrepreneurs, industry, and leading academics across Europe. In recent years, Ridgeline has assembled an international team of >50 highly experienced drug discovery and industry professionals and built and operated multiple new successful companies; these companies have raised significant funds through Series B, IPO and an exit through a trade sale.

Join our Basel-based portfolio company Serac Biosciences AG as a motivated Research Associate and become an enthusiastic team player in a fast-paced start-up environment, where you can make a real impact in a vibrant and agile biotech setting.

Key RESPONSIBILITIES

• Support both routine research activities and more in-depth profiling studies by performing cell-based and biochemical/biophysical studies to assist with the identification, validation, prioritization and benchmarking of small molecule protein degraders.
• Perform a wide variety of medium- to high-throughput profiling workflows with cell-based and biochemical formats.
• Streamline operation and processes using semi- or full automation to meet timelines and team objectives.
• Independently design, conduct, and summarize data for key experiments to progress projects. Troubleshoot and implement solutions when required.
• Maintain thorough documentation and written records of experimental and data in lab notebooks and communicate results in a clear/concise manner in internal meetings.
• Contribute to laboratory general organization and maintenance, manage laboratory stocks and ordering.
• Ensure compliance with good laboratory practices including safety regulations, data management, data recording in electronic notebooks and archiving.
• Keen interest in understanding the current literature surrounding TPD and specific targets of interest.

QUALIFICATIONS

• Bachelor’s/master’s degree in biology/cell-biology (focus on small molecule profiling), biochemistry/biophysics/biotechnology (with cell-biology experience), or related field. This position is not suitable for PhD level or above.
• Or laboratory apprenticeship with 2+ years relevant drug discovery experience in biotech or pharma.
• Experience with basic techniques related to biochemistry, biophysics and small molecule handling required, e.g. FP, TSA, SPR.
• Experience with basic techniques related to mammalian cell-culture and assays required, e.g. BRET, Western Blot, ELISA, IP.
• Experience with FACS considered a plus.
• Working experience in targeted protein degradation (molecular glue, PROTACs and related) considered a plus.
• Must be able to work well in a highly collaborative team-oriented environment. Capable of thriving and multi-tasking in a fast-paced “start-up” environment.
• Self-motivated, willingness to learn, strong work ethic, attention to detail, organizational skills, and excellent communication skills are required for this position.
• Proficiency in utilizing general and specialized software such as Microsoft office, Prism, ELN etc., for data analysis and figure generation.
• Fluency in English required.

• Offices: Our well-equipped laboratories and offices are located at the Tech Park, a premier address for early-stage start-ups in Basel.
• Commuter Benefits: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
• Flexible Working: We support flexible working as appropriate.
• Christmas Closure: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
• Birthday Retreat: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.
• Food: We like get-togethers during lunch time. Enjoy tasty, subsidised meals from our FELFEL food fridge.
• Coffee: Meet up with your colleagues and grab free coffee.
• Development: We support the individual development of our employees.
• Creativity: We offer an innovative and creative environment.
• People: We are an international and diverse team with talented and passionate people.
• Fun: From time-to-time we organise cool off-site summer and winter team events.

Please send us your CV and Cover letter until December 18th, 2025.